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BOUDRY, SWITZERLAND--( / ) January 28, 2015 -- Celgene International Sarl, a wholly owned subsidiary of Celgene Corporation (NASDAQ: CELG), today announced that the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for ABRAXANE® (paclitaxel formulated as albumin-bound nanoparticles, or nab-paclitaxel) in combination with carboplatin for the first-line treatment of non-small cell lung cancer in adult patients who are not candidates for potentially curative surgery and/or radiation therapy.

Lung cancer is the fourth most commonly diagnosed cancer in both men and women, however it is the leading cause of cancer-related mortality in Europe. Non-small cell lung cancer (NSCLC) is the most common form of lung cancer, accounting for 85 to 90% of all cases. The predominant cause of lung cancer is cigarette smoking, although environmental and occupational factors also can cause the cancer. Treatment options generally include systemic chemotherapy or protein kinase inhibitors. In the most advanced cases, only the symptoms of the disease can be managed; there is a clear need for innovative new medicines for the treatment of lung cancer.

“Progress in lung cancer will come first from early diagnosis with patients presenting promptly with symptoms and second, with new drugs that are well tolerated and improve on current therapies. Incremental steps can lead to a meaningful impact on patients and society, given the frequency and aggressiveness of lung cancer,” says Dr. Mary O’Brien, Consultant Medical Oncologist at The Royal Marsden NHS Foundation Trust, UK. “The positive CHMP opinion for ABRAXANE in combination with carboplatin for the treatment of adult patients with NSCLC is a significant step toward bringing a new treatment option to patients in Europe. The clinical data show patients had a significant positive response rate to the treatment, combined with an established safety profile. The therapy has also shown a significant response benefit for a subset of patients with squamous cell lung cancer, where there have been limited treatment advances in recent years.”

The positive CHMP opinion was based on the results of a multicenter, randomized, open-label study including 1,052 chemotherapy-naive patients with Stage IIIb/IV non-small cell lung cancer. The study compared ABRAXANE in combination with carboplatin versus solvent-based paclitaxel in combination with carboplatin as first-line treatment in patients with advanced non-small cell lung cancer. The primary efficacy endpoint, overall response rate, was significantly higher for patients in the ABRAXANE/carboplatin arm at 33%, compared with patients in the control arm, at 25%. The most common adverse reactions

(≥ 20%) of ABRAXANE in combination with carboplatin for NSCLC were anaemia, neutropenia, thrombocytopenia, peripheral neuropathy, nausea, and fatigue.

Tuomo Patsi, President of Celgene in Europe, the Middle East and Africa (EMEA), said, “The positive CHMP opinion is the first opportunity for Celgene to play a role in helping patients with NSCLC have access to an important treatment option in Europe. The anticipated European Commission decision would be the third approved indication for ABRAXANE, underscoring the value of this medicine. We are committed to ensuring that patients who need ABRAXANE will gain access to it once approved by the European Commission.”

The CHMP reviews applications for all 28 member states in the European Union (EU), as well as Norway, Liechtenstein and Iceland. The European Commission, which generally follows the recommendation of the CHMP, is expected to make its final decision within approximately two months. If approval is granted, detailed conditions for the use of this product will be described in the Summary of Product Characteristics (SmPC), which will be published in the revised European Public Assessment Report (EPAR).

ABRAXANE is not currently indicated for the treatment of metastatic NSCLC in the European Union.

About ABRAXANE

ABRAXANE® is an albumin-bound form of paclitaxel that is manufactured using patented nab® technology. ABRAXANE is formulated with albumin, a human protein, and is free of solvents.

ABRAXANE was first approved in January 2005 by the U.S. Food and Drug Administration (FDA) for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Prior therapy should have included an anthracycline unless clinically contraindicated. In Europe, ABRAXANE was approved in January 2008 as monotherapy for the treatment of metastatic breast cancer in adult patients who have failed first-line treatment for metastatic disease and for whom standard, anthracycline containing therapy is not indicated. ABRAXANE is now approved in more than 50 countries for the treatment of metastatic breast cancer.

In October 2012, ABRAXANE was approved by the FDA for the first-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC), in combination with carboplatin, in patients who are not candidates for curative surgery or radiation therapy. ABRAXANE is also approved for the treatment of NSCLC in Argentina, Australia, Chile, Ecuador, Guatemala, Hong Kong, Japan, New Zealand and Singapore.

In September 2013, the FDA approved ABRAXANE as first-line treatment of patients with metastatic adenocarcinoma of the pancreas, in combination with gemcitabine. In December 2013, ABRAXANE in combination with gemcitabine was approved for first-line treatment of adult patients with metastatic adenocarcinoma of the pancreas in Europe. ABRAXANE is also approved for the treatment of metastatic pancreatic cancer in more than 40 countries.

U.S. Regulatory Information for ABRAXANE

WARNING - NEUTROPENIA

· Do not administer ABRAXANE therapy to patients who have baseline neutrophil counts of less than 1500 cells/mm3. In order to monitor the occurrence of bone marrow suppression, primarily neutropenia, which may be severe and result in infection, it is recommended that frequent peripheral blood cell counts be performed on all patients receiving ABRAXANE

· Note: An albumin form of paclitaxel may substantially affect a drug’s functional properties relative to those of drug in solution. DO NOT SUBSTITUTE FOR OR WITH OTHER PACLITAXEL FORMULATIONS

CONTRAINDICATIONS

Neutrophil Counts

· ABRAXANE should not be used in patients who have baseline neutrophil counts of <1500 cells/mm3

Hypersensitivity

· Patients who experience a severe hypersensitivity reaction to ABRAXANE should not be rechallenged with the drug

WARNINGS AND PRECAUTIONS

Hematologic Effects

· Bone marrow suppression (primarily neutropenia) is dose-dependent and a dose-limiting toxicity of ABRAXANE. In clinical studies, Grade 3-4 neutropenia occurred in 34% of patients with metastatic breast cancer (MBC), 47% of patients with non-small cell lung cancer (NSCLC), and 38% of patients with pancreatic cancer

· Monitor for myelotoxicity by performing complete blood cell counts frequently, including prior to dosing on Day 1 (for MBC) and Days 1, 8, and 15 (for NSCLC and for pancreatic cancer)

· Do not administer ABRAXANE to patients with baseline absolute neutrophil counts (ANC) of less than 1500 cells/mm3

· In the case of severe neutropenia (<500 cells/mm3 for 7 days or more) during a course of ABRAXANE therapy, reduce the dose of ABRAXANE in subsequent courses in patients with either MBC or NSCLC

· In patients with MBC, resume treatment with every-3-week cycles of ABRAXANE after ANC recovers to a level >1500 cells/mm3 and platelets recover to a level >100,000 cells/mm3

· In patients with NSCLC, resume treatment if recommended at permanently reduced doses for both weekly ABRAXANE and every-3-week carboplatin after ANC recovers to at least 1500 cells/mm3 and platelet count of at least 100,000 cells/mm3 on Day 1 or to an ANC of at least 500 cells/mm3 and platelet count of at least 50,000 cells/mm3 on Days 8 or 15 of the cycle

· In patients with adenocarcinoma of the pancreas, withhold ABRAXANE and gemcitabine if the ANC is less than 500 cells/mm3 or platelets are less than 50,000 cells/mm3 and delay initiation of the next cycle if the ANC is less than 1500 cells/mm3 or platelet count is less than 100,000 cells/mm3 on Day 1 of the cycle. Resume treatment with appropriate dose reduction if recommended

Nervous System

· Sensory neuropathy is dose- and schedule-dependent

· The occurrence of Grade 1 or 2 sensory neuropathy does not generally require dose modification

· If ≥ Grade 3 sensory neuropathy develops, withhold ABRAXANE treatment until resolution to Grade 1 or 2 for MBC or until resolution to ≤ Grade 1 for NSCLC and pancreatic cancer followed by a dose reduction for all subsequent courses of ABRAXANE

Sepsis

· Sepsis occurred in 5% of patients with or without neutropenia who received ABRAXANE in combination with gemcitabine

· Biliary obstruction or presence of biliary stent were risk factors for severe or fatal sepsis

· If a patient becomes febrile (regardless of ANC), initiate treatment with broad-spectrum antibiotics

· For febrile neutropenia, interrupt ABRAXANE and gemcitabine until fever resolves and ANC ≥1500 cells/mm3, then resume treatment at reduced dose levels

Pneumonitis

· Pneumonitis, including some cases that were fatal, occurred in 4% of patients receiving ABRAXANE in combination with gemcitabine

· Monitor patients for signs and symptoms and interrupt ABRAXANE and gemcitabine during evaluation of suspected pneumonitis

· Permanently discontinue treatment with ABRAXANE and gemcitabine upon making a diagnosis of pneumonitis

Hypersensitivity

· Severe and sometimes fatal hypersensitivity reactions, including anaphylactic reactions, have been reported

· Patients who experience a severe hypersensitivity reaction to ABRAXANE should not be rechallenged with this drug

Hepatic Impairment

· Because the exposure and toxicity of paclitaxel can be increased with hepatic impairment, administration of ABRAXANE in patients with hepatic impairment should be performed with caution

· Patients with hepatic impairment may be at an increased risk of toxicity, particularly from myelosuppression, and should be monitored for development of profound myelosuppression

· For MBC and NSCLC, the starting dose should be reduced for patients with moderate or severe hepatic impairment

· For pancreatic adenocarcinoma, ABRAXANE is not recommended for patients with moderate to severe hepatic impairment (total bilirubin >1.5 x ULN and AST ≤10 x ULN)

Albumin (Human)

· ABRAXANE contains albumin (human), a derivative of human blood

Use in Pregnancy: Pregnancy Category D

· ABRAXANE can cause fetal harm when administered to a pregnant woman

· If this drug is used during pregnancy, or if the patient becomes pregnant while receiving this drug, the patient should be apprised of the potential hazard to the fetus

· Women of childbearing potential should be advised to avoid becoming pregnant while receiving ABRAXANE

Use in Men

· Men should be advised not to father a child while receiving ABRAXANE

ADVERSE REACTIONS

Randomized Metastatic Breast Cancer (MBC) Study

· The most common adverse reactions (≥20%) with single-agent use of ABRAXANE vs paclitaxel injection in the MBC study are alopecia (90%, 94%), neutropenia (all cases 80%, 82%; severe 9%, 22%), sensory neuropathy (any symptoms 71%, 56%; severe 10%, 2%), abnormal ECG (all patients 60%, 52%; patients with normal baseline 35%, 30%), fatigue/asthenia (any 47%, 39%; severe 8%, 3%), myalgia/arthralgia (any 44%, 49%; severe 8%, 4%), AST elevation (any 39%, 32%), alkaline phosphatase elevation (any 36%, 31%), anemia (any 33%, 25%; severe 1%, <1%), nausea (any 30%, 22%; severe 3%, <1%), diarrhea (any 27%, 15%; severe <1%, 1%) and infections (24%, 20%), respectively

· Sensory neuropathy was the cause of ABRAXANE discontinuation in 7/229 (3%) patients

· Other adverse reactions of note with the use of ABRAXANE vs paclitaxel injection included vomiting (any 18%, 10%; severe 4%, 1%), fluid retention (any 10%, 8%; severe 0%, <1%), mucositis (any 7%, 6%; severe <1%, 0%), hepatic dysfunction (elevations in bilirubin 7%, 7%), hypersensitivity reactions (any 4%, 12%; severe 0%, 2%), thrombocytopenia (any 2%, 3%; severe <1%, <1%), neutropenic sepsis (<1%, <1%), and injection site reactions (<1%, 1%), respectively. Dehydration and pyrexia were also reported

· Renal dysfunction (any 11%, severe 1%) was reported in patients treated with ABRAXANE (n=229)

· In all ABRAXANE-treated patients (n=366), ocular/visual disturbances were reported (any 13%; severe 1%)

· Severe cardiovascular events possibly related to single-agent ABRAXANE occurred in approximately 3% of patients and included cardiac ischemia/infarction, chest pain, cardiac arrest, supraventricular tachycardia, edema, thrombosis, pulmonary thromboembolism, pulmonary emboli, and hypertension

· Cases of cerebrovascular attacks (strokes) and transient ischemic attacks have been reported

Non-Small Cell Lung Cancer (NSCLC) Study

· The most common adverse reactions (≥20%) of ABRAXANE in combination with carboplatin are anemia, neutropenia, thrombocytopenia, alopecia, peripheral neuropathy, nausea, and fatigue

· The most common serious adverse reactions of ABRAXANE in combination with carboplatin for NSCLC are anemia (4%) and pneumonia (3%)

· The most common adverse reactions resulting in permanent discontinuation of ABRAXANE are neutropenia (3%), thrombocytopenia (3%), and peripheral neuropathy (1%)

· The most common adverse reactions resulting in dose reduction of ABRAXANE are neutropenia (24%), thrombocytopenia (13%), and anemia (6%)

· The most common adverse reactions leading to withholding or delay in ABRAXANE dosing are neutropenia (41%), thrombocytopenia (30%), and anemia (16%)

· The following common (≥10% incidence) adverse reactions were observed at a similar incidence in ABRAXANE plus carboplatin-treated and paclitaxel injection plus carboplatin-treated patients: alopecia (56%), nausea (27%), fatigue (25%), decreased appetite (17%), asthenia (16%), constipation (16%), diarrhea (15%), vomiting (12%), dyspnea (12%), and rash (10%); incidence rates are for the ABRAXANE plus carboplatin treatment group

· Adverse reactions with a difference of ≥2%, Grade 3 or higher, with combination use of ABRAXANE and carboplatin vs combination use of paclitaxel injection and carboplatin in NSCLC are anemia (28%, 7%), neutropenia (47%, 58%), thrombocytopenia (18%, 9%), and peripheral neuropathy (3%, 12%), respectively

· Adverse reactions with a difference of ≥5%, Grades 1-4, with combination use of ABRAXANE and carboplatin vs combination use of paclitaxel injection and carboplatin in NSCLC are anemia (98%, 91%), thrombocytopenia (68%, 55%), peripheral neuropathy (48%, 64%), edema peripheral (10%, 4%), epistaxis (7%, 2%), arthralgia (13%, 25%), and myalgia (10%, 19%), respectively

· Neutropenia (all grades) was reported in 85% of patients who received ABRAXANE and carboplatin vs 83% of patients who received paclitaxel injection and carboplatin

Pancreatic Adenocarcinoma Study

· Among the most common (≥20%) adverse reactions in the phase III study, those with a ≥5% higher incidence in the ABRAXANE/gemcitabine group compared with the gemcitabine group are neutropenia (73%, 58%), fatigue (59%, 46%), peripheral neuropathy (54%, 13%), nausea (54%, 48%), alopecia (50%, 5%), peripheral edema (46%, 30%), diarrhea (44%, 24%), pyrexia (41%, 28%), vomiting (36%, 28%), decreased appetite (36%, 26%), rash (30%, 11%), and dehydration (21%, 11%)

· Of these most common adverse reactions, those with a ≥2% higher incidence of Grade 3-4 toxicity in the ABRAXANE/gemcitabine group compared with the gemcitabine group, respectively, are neutropenia (38%, 27%), fatigue (18%, 9%), peripheral neuropathy (17%, 1%), nausea (6%, 3%), diarrhea (6%, 1%), pyrexia (3%, 1%), vomiting (6%, 4%), decreased appetite (5%, 2%), and dehydration (7%, 2%)

· Thrombocytopenia (all grades) was reported in 74% of patients in the ABRAXANE/gemcitabine group vs 70% of patients in the gemcitabine group

· The most common serious adverse reactions of ABRAXANE (with a ≥1% higher incidence) are pyrexia (6%), dehydration (5%), pneumonia (4%), and vomiting (4%)

· The most common adverse reactions resulting in permanent discontinuation of ABRAXANE were peripheral neuropathy (8%), fatigue (4%), and thrombocytopenia (2%)

· The most common adverse reactions resulting in dose reduction of ABRAXANE are neutropenia (10%) and peripheral neuropathy (6%)

· The most common adverse reactions leading to withholding or delay in ABRAXANE dosing are neutropenia (16%), thrombocytopenia (12%), fatigue (8%), peripheral neuropathy (15%), anemia (5%), and diarrhea (5%)

· Other selected adverse reactions with a ≥5% higher incidence for all-grade toxicity in the ABRAXANE/gemcitabine group compared to the gemcitabine group, respectively, are asthenia (19%, 13%), mucositis (10%, 4%), dysgeusia (16%, 8%), headache (14%, 9%), hypokalemia (12%, 7%), cough (17%, 7%), epistaxis (15%, 3%), urinary tract infection (11%, 5%), pain in extremity (11%, 6%), arthralgia (11%, 3%), myalgia (10%, 4%), and depression (12%, 6%)

· Other selected adverse reactions with a ≥2% higher incidence for Grade 3-4 toxicity in the ABRAXANE/gemcitabine group compared to the gemcitabine group are thrombocytopenia (13%, 9%), asthenia (7%, 4%), and hypokalemia (4%, 1%)

Postmarketing Experience With ABRAXANE and Other Paclitaxel Formulations

· Severe and sometimes fatal hypersensitivity reactions have been reported with ABRAXANE. The use of ABRAXANE in patients previously exhibiting hypersensitivity to paclitaxel injection or human albumin has not been studied

· There have been reports of congestive heart failure, left ventricular dysfunction, and atrioventricular block with ABRAXANE, primarily among individuals with underlying cardiac history or prior exposure to cardiotoxic drugs

· There have been reports of extravasation of ABRAXANE. Given the possibility of extravasation, it is advisable to monitor closely the ABRAXANE infusion site for possible infiltration during drug administration

DRUG INTERACTIONS

· Caution should be exercised when administering ABRAXANE concomitantly with medicines known to inhibit or induce either CYP2C8 or CYP3A4

USE IN SPECIFIC POPULATIONS

Nursing Mothers

· It is not known whether paclitaxel is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother

Pediatric

· The safety and effectiveness of ABRAXANE in pediatric patients have not been evaluated

Geriatric

· No toxicities occurred notably more frequently among patients ≥65 years of age who received ABRAXANE for MBC

· Myelosuppression, peripheral neuropathy, and arthralgia were more frequent in patients ≥65 years of age treated with ABRAXANE and carboplatin in NSCLC

· Diarrhea, decreased appetite, dehydration, and epistaxis were more frequent in patients 65 years or older compared with patients younger than 65 years old who received ABRAXANE and gemcitabine in adenocarcinoma of the pancreas

Renal Impairment

· There are insufficient data to permit dosage recommendations in patients with severe renal impairment or end stage renal disease (estimated creatinine clearance <30 mL/min)

DOSAGE AND ADMINISTRATION

TAIPEI, TAIWAN--( / ) November 04, 2014 -- The 2014 UFI Congress is being held in Bogota, Colombia from October 29th to November 1st. In the spotlight of this year’s congress is COMPUTEX TAIPEI, as 온라인카지노순위 TAIPEI,receives the award for winning the coveted UFI Marketing Award. UFI President, Renaud Hamaide, and UFI Marketing Committee Chair, Christian Glasmacher, presented the award to TAITRA Executive Vice President Walter Yeh. VIP guests at the ceremony also included Representative Ji-zen Tang and members of the Economic Division, Taipei Commercial Office in Bogota, Colombia.

Also known as the Oscars of the MICE industry, the UFI Marketing Award draws the best organizers in MICE from all over the world as they vie for the prestigious award. This year’s award focuses on Mobile Marketing, 로투스바카라필승법 Also the judging panel 바카라배팅전략 AlsoSeptember 5th in Verona, Italy. The organizing team behind TAITRA’S successful COMPUTEX beat out the competition from many prestigious international shows with the show’s exclusive app and its visitor-friendly features?such as in-hall positioning and navigation and NFC-based visitor data collection?as well as other customized services like free in-venue Wi-Fi, 바카라배팅타이밍 Alsobadges embedded with RFID chips for complimentary and unlimited Taipei metro access, and buyers’ procurement meeting pre-registration, to take home the UFI Marking Award. This award is the highest honor in Taiwan’s 41 years in the MICE industry.

UFI has also announced during this year’s Congress that TAITRA Executive Vice 바카라필승전략 UFIWalter Yeh has been elected as one of UFI’s directors and presides over the Asia-Pacific region alongside the PRC, Japan, Korea, and India. UFI directors serve 3-year terms, during which they cultivate international MICE. Walter 바카라불패신화 UFIjoined the Board in 2014 and will continue to expand Taiwan’s MICE industry overseas.

Photos/Multimedia Gallery Available:Korea 바카라전략슈 Photos/Multimediadistributes your 바카라그림보는법 Photos/Multimediaacross every media channels through the industry’s largest press release distribution 바카라패턴 Photos/Multimedia

바로가기 : 마카오카지노 사설토토 여자가슴사진 지옥넷야동 밤에만넷성인 휴지킹일본야동 야왕막힘 폭시에브링크 무료황금성 배너모아 av순위 최신온라인게임 베트남호텔카지노 먹튀사이트 야마토게임장 무료실시간tv어플 고니카지노 딸통령주소 자선냄비성인 캐나다카지노 analdin우회 벳인포 야마토4pc버전 골든크로스 Pervclips성인 딸자닷컴트위터 2019정야마토 성인물 신던스타킹 밤에만넷커뮤니티 보솜이서양야동 스포츠조이 다빈치 딸잡go막힘 다빈치정보 폰허브접속 일배야같은사이트 위야넷트위터 관음증 제왕카지노 현금야마토 떡지도사이트 야만화 일본콘돔 펑키서버 밤열한시닷컴접속 마사회 인터넷양귀비 pornwhite서버 야덩 밤에남자새주소 바둑이사이트 텀블소막힘 펑키서양야동 코리아카지노 나체촌 떡지도서버 섹시화보 JAV베드서버 꿀떡넷주소 인터넷다빈치 야구문자중계 도신닷컴사이트 데일리비디오사이트 야한동영상 외국야동사이트 쿵쾅닷컴우회 HOTSCOPE서양야동 아프리카섹시댄스 웹툰스타 노블타운커뮤니티 소라넷일탈우회 위야넷일본야동 야구리막힘 엠카지노 69맥심사이트 꽁머니 젖팔계우회 pornhat링크 WBC247 PORNDIG새주소 야마토2014주소 여자거기 PORNDIG우회 모아따새주소 봉지닷컴성인 야플TV서양야동 HOTSCOPE우회 누두 온라인게임정보 은교넷새주소 일배야서버 밤왕트위터 한국영화 홍도깨비주소 고구마우회 진짜야마토 야동조아같은사이트 카지노알바 온라인게임 69맥심같은사이트 폭시에브우회 쩍벌댄스 여비서막힘 최신야동 야한생각 맥스카지노 첫섹스 아프리카tv먹방 일본에로배우 양귀비 무료릴게임 고니카지노 여비서서버 영톡 analdin일본야동 밤에만넷커뮤니티 wankoz 개조아 더블업카지노 세부호텔카지노 자선냄비서양야동 고추클럽같은사이트 야동동영상 새만금카지노 야마토3온라인게임 통기계버전 신정환카지노 두리안사이트 다모아바카라 릴게임사이트정보 야마토신뢰도 성인채팅 젖팔계새주소 온라인릴게임정보 섹코막힘 에그벳 무료성인동영상 두리안접속 야마토4통기계 황금성 오프라인야마토게임장 라이브경마 일베야 야마토게임장 AVMANY트위터 JAVJOB 야동공장서버 성인채널 vporn주소 조이티비 tube8서버 통기계버전 성인사이트추천 일본콘돔 야한싸이트 온라인무료바다이야기 베스트초이스일본야동 밤꽃우회 성인용품점 누나넷 Strommen 여자수영복 플레이코리아 도신닷컴우회 섹스동영상 휴지랑서버 챔스 일본그라비아 PornTube커뮤니티 COD 소라조아새주소 야마토게임장 야동만화 구르마넷서버 인터넷방송사이트 에그벳 지옥넷일본야동 무료온라인게임사이트 섹스하는사진 펑키우회 황금성5 골드카지노 연애그참을수없는가벼움 서양누드 온라인야마토3 오프라인야마토 데일리비디오사이트 처녀막재생 온라인게임갤러리 노블타운성인 ibcbet 야한천사막힘 온라인야마토5 라이브스코어인증번호 섹시영화 AV팝우회 야구리서양야동 바나나티비우회 조개파티주소찾기 소리넷서양야동 골뱅이커뮤니티 야마토연타 부산경륜 야한동영상 vporn트위터 NKMaribor 미단시티카지노 모아따일본야동 애니메이션 스포츠토토배당률 현자타임즈밤에맨 레즈비언섹스 안전놀이터 에로 다모아카지노 코리아비디오 FETISH 구성애 여자도끼 보솜이일본야동 당신의스포츠와함께합니다.스포츠토토 온라인게임 다모아카지노 일배야서양야동 오나니같은사이트 채팅사이트 바나나TV 도끼자국 색마블 노블타운접속 알라딘최신버전 조또TV 황금성5 젖팔계주소 2018황금성 스포츠토토배당률 야마토추천인 우리넷접속 구르마넷트위터 야마토5게임하기 먹튀보상 야동파일일본야동 야동넷우회 폭시에브서양야동 미시녀 여자흥분 HOTSCOPE사이트 일본야한만화 새만금카지노 pornhat커뮤니티 꽁머니 밤에만넷새주소 스카이러브 LetFap새주소 케이팝딥페이크성인 먹튀검증커뮤니티 폰허브일본야동 소라스포같은사이트 케이티비주소 남자누드 카지노바카라 AVMANY야동 AVMANY접속 일본그라비아모델 소리넷성인 메가스포츠야마토릴게임 밤에만넷주소 sexygirls 2016황금성 아키호요시자와 슈어맨 데일리비디오주소 youporn새주소 HOTSCOPE같은사이트 슈어맨2미스터그린 야마토5게임동영상 19곰닷컴 진짜야마토 먹튀신고 카지노바카라 야동판우회 PLAYBOY 진짜야마토 M카지노 야부리주소 먹튀신고 최신버전 패티시 씹구멍링크 검증된놀이터 야한플래시 먹튀폴리스 youporn 소라조아서양야동 wankoz같은사이트 여캠방19 야외섹스 야동섹스 야동넷새주소 노블타운트위터 먹튀폴리스심바 성방 analdin트위터 메간폭스 야마토5공략 오이넷서양야동 송송넷접속 성인영화 골프 꿀떡넷성인 밍키넷주소찾기 고추클럽막힘 가위치기 AOZ 야동조아서버 먹튀검증업체순위 뒤태 인스타그램검색 슈어맨삽니다 야동추천 파워볼수익내기 올맨주소찾기 AV노리같은사이트 펑키 호카지노 얼사 연타잭팟 야마토3동영상 바카라노하우 야동조아성인 FETISH 골드카지노 케이팝딥페이크링크 비비카지노 야마토새우 네임드파워볼 파워볼예측 딸자닷컴일본야동 이하얀 휴지킹트위터 두리안사이트 즐톡 올맨막힘 야왕서양야동 요시자와 씹구멍같은사이트 위야넷같은사이트 노블타운링크 트윗 늑대비디오접속 엔트리파워볼분석기 탑툰 누나곰닷컴링크 Pervclips커뮤니티 두리안커뮤니티 69맥심우회 아프리카19 콕이오예능 엉덩이노출 섹스피스톨즈 떡마차막힘 자놀야동 19만화 야한 데일리비디오커뮤니티 엔트리파워볼분포도 알몸 야마토다운로드 드래곤8카지노 밀리언클럽카지노 엔트리파워볼패턴 떡마차접속 인터넷방송갤러리 2019정야마토 고추클럽같은사이트 딸딸나라서양야동 TPRTM AP코믹스 밤열한시닷컴주소찾기 오프라인야마토게임 동행복권파워볼 카지노에이전시 심톡 베네시안호텔카지노 PORNDIG트위터 네임드파워볼 youporn야동 소라걸스커뮤니티 릴게임프로그램 큰가슴 딸구닷컴서버 해소넷서버 youporn링크 미미123링크 콘돔파는곳 키노사다리짝배팅 구르마넷링크 19애니 딸잡go같은사이트 워커힐카지노 고스톱치는법 AVDDR주소 온라인야마토6 아시안커넥트 tube8 한국성인영화 여자꼬시는법 tube8같은사이트 호두코믹스 소라넷사이트 휴지랑주소 PornTube우회 부부섹스 실시간야동 섹스하는동영상 피망맞고 여자친구 야구리서버 꽁딸시즌2우회 모아따같은사이트 Pervclips막힘 데일리비디오새주소 영종도카지노 성인인증 조또TV LetFap접속 떡마차같은사이트 뒤태 펑키일본야동 지옥넷접속 고스톱최고점수 제왕카지노 야마토온라인3 피망뉴맞고forkakaoAPK 부산호텔카지노 캔디넷우회 딸기넷서양야동 밍키넷성인 69맥심성인 나체사진 40대채팅 젖팔계같은사이트 맞고룰 온라인릴게임사이트 일배야서버 고스톱고 세븐포커족보 떡마차야동 솔레어카지노 여비서링크 여자찌찌 해소넷주소찾기 섹스사이트 PornTube일본야동 탑툰 소라조아일본야동 케이팝딥페이크우회 오딸넷같은사이트 pornhat서양야동 섯다기술 섯다기술 삼팔광땡 고스톱나는점수 SEXWAL 조개파티주소 69맥심같은사이트 69맥심링크 조또TV접속 SEXY 한국에로 야플TV일본야동 도신닷컴성인 꿀떡넷주소 오나니우회 바나나티비접속 고스톱고 Txxx서양야동 타짜카지노 AV노리주소 젖소넷 붕가붕가 벗방순위 송송넷주소찾기 꽁딸시즌2야동 18모아4새주소 물사냥성인 에이플러스카지노 황금성온라인 노블타운주소찾기 야마토릴게임 딸타임 LetFap서양야동 야마토사이트 소라바다링크 바카라노하우 성인채팅 제왕카지노 HOTSCOPE 일반인누드 에스피연타 무료야마토게임 카심바카지노 펑키주소찾기 가위치기 온라인신천지 최신바다이야기 AV팝접속 야마토3통기계 맥스카지노 야동판새주소 애인찾기 황금성3 스보벳 캔디넷일본야동 황금성 바다이야기게임 우리넷커뮤니티 AV팝사이트 야한사람 노블타운일본야동 야왕링크 야마토릴게임 홍도깨비야동 미팅 네토닷컴야동 어우동티비 AVMANY성인 SEXY 성교육영상 2015황금성 밤꽃같은사이트 도신닷컴주소찾기 케이팝딥페이크주소찾기 딸딸나라막힘 야킹링크 무료야마토게임 야한이야기 여성생식기 이비자넷막힘 무료결혼정보회사 자위하는법 무료꽁짜릴게임 봉지닷컴 송송넷서버 꽁딸시즌2우회 지옥넷서버 피나야 누나넷 부산채팅 현금야마토 우리바카라 바다이야기게임다운 일배야우회 야인링크 섹시걸 채찍 Txxx접속 무료야한사이트 조개파티트위터 꽁딸시즌2같은사이트 슬림콘돔 폰허브주소찾기 노블타운주소 지옥넷일본야동 애플카지노 현금야마토 떡마차서양야동 AVMANY접속 섹코주소 조개넷서양야동 일배야우회 온라인다빈치 딸자닷컴서양야동 영상요청 떡지도트위터 볼개그 미소넷주소 꿀떡넷새주소 AVMANY접속 ADULT 릴게임추천 HOTSCOPE일본야동 윈스카지노 검증사이트 성인망가 야마토현금 우리넷막힘 섹시천사서양야동 업소베스트 미미주소찾기 콘돔회사 섹코야동 오입질 딸구닷컴서양야동 18모아주소변경 야한것 릴게임추천 바로연 모아따트위터 바나나물 서윤 섹스보조기구 정통바카라 휴지랑성인 성인옹품 여자수갑 얼싸 야플TV사이트 여고생스타킹 도신닷컴주소찾기 여자찌찌 젖팔계사이트 야한야동 올맨주소찾기 무료성인동영상 핫밤 일본야한만화 서윤19 오이넷같은사이트 여자도끼 LELO 조개파티서버 성인상품 만남 폭딸넷막힘 tube8주소 양귀비 야만닷컴커뮤니티 야색마막힘 송송넷일본야동 미시녀 야외노출 야베스트사이트 성기강화 팬티냄새 성인용품콘돔 퍼스트카지노 휴지킹서양야동 야한이야기 오이넷같은사이트 리포푼딘 케이팝딥페이크트위터 네토닷컴사이트 구르마넷같은사이트 성인게임장돈따는법 라라TV 성인병에좋은음식 섹스 조개파티주소찾기 일배야서버 야찾사주소 골든크로스 밤딸기주소찾기 젖팔계성인 성인용품 젝스트 젖팔계일본야동 AVDDR주소 싱가포르카지노 섹스보기 구르마넷같은사이트 미미123서버 밤헌터새주소 야마토정보제공 꽁딸시즌2접속 야동판일본야동 이비자넷우회 스마트폰방송 황금성게임다운로드 AV노리커뮤니티 야일라 여자사정 pornwhite우회 고추클럽서버 도신닷컴 올스포츠웹툰 세계대전야마토 리쏘제니스 외국야동사이트 2019바다이야기게임 남자누드 섹시천사서양야동 인터넷방송19 JAV베드우회 밤에만넷접속 리피토 AVDDR일본야동 야마토7 딸북스주소 2012야마토 가위치기 JAV베드커뮤니티 야인트위터 올벳카지노 바나나티비트위터 블랙잭노하우 콘돔구매 PORNDIG 데일리비디오트위터 18moa01새주소 레이저채혈기 야플TV서양야동 데일리비디오주소찾기 섹코성인 정사 인터넷양귀비 여캠bj 밤의전쟁 소라바다트위터 가가라이브랜덤채팅 야마토3온라인게임 성 watchmygf서양야동 케이팝딥페이크접속 AV노리커뮤니티 비아그라처방 성인동 애플카지노 자선냄비일본야동 알라딘최신버전 와이즈토토승무패 vporn막힘 오마담 꿀떡넷주소 베스트초이스 현금야마토 AVDDR같은사이트 눈요기 실시간tv 밤딸기주소찾기 야구리서양야동 인터넷성인릴게임 밤에만넷우회 유두클립 해소넷막힘 바카라사이트쿠폰 부산야마토 누드모델 정선카지노 야동판같은사이트 부산파라다이스카지노 2019바다이야기릴게임 크라운카지노 이비자넷 youporn pornwhite서버 2019바다이야기게임장 섹스테크닉 밤의신링크 딸딸나라주소 남편외도 2011바다이야기 18moa4최신주소 자위동영상 HOTSCOPE야동 누나넷접속 야마토신뢰도 2019황금성 야인주소찾기 지옥넷트위터 체위종류 야한천사서양야동 2020야마토 JAV베드커뮤니티 소라바다일본야동 섹스몰 bj소진 조또TV서버 밤에만넷접속 AV팝사이트 노블타운사이트 밍키넷새주소 오나니야동 soranet 웹툰모아 폰허브사이트 오피걸닷컴 야마토통기계버전 썬시티카지노 야외섹스 남성성기확대 JAV베드접속 딸통령성인 소라넷일탈막힘 야왕일본야동 빠찡코 Txxx주소 에로영화 미미일본야동 인터넷PC게임 야동공장성인 파워볼구간보는법 온라인다빈치 야구리성인 벨라지오카지노 소라넷 그라비아일본 항문삽입 더나인카지노 야플TV서버 베네시안카지노 Pervclips링크 WBC247 1:1방송 자놀같은사이트 제이제이 분수넷서버 여자가슴노출 소음순모양 케이티비트위터 우리넷접속 코미코 19세야동 릴게임추천 펑키접속 콘돔판매 질쪼임 마카오카지노 야한사이트 폰허브주소찾기 LetFap막힘 AVMANY커뮤니티 호카지노 일배야야동 야마토릴게임 위야넷링크 4tube서버 맛있는섹스그리고사랑 야마토5공략 올맨링크 듀렉스돌기 허봉넷야동 야인막힘 비아그라약국판매가격 걸천사일본야동 디시인사이드모바일 한국야동 오딸넷트위터 크라운카지노 강원랜드친구들 젖팔계커뮤니티 무료야마토게임 다이사이 야동 카지노에이전시 사다리게임 맨스 두리안서버 야동파일링크 밍키우회 소리넷서양야동 울트라씬 Txxx링크 일회용알콜솜 우주전함 딸통령접속 누나넷우회 야동사이트 야마토게임장 자선냄비커뮤니티 성인상품 무료성인동영상 오리엔탈카지노 딸북스막힘 AV노리야동 TUBXPORN야동 폭딸넷링크 야마토3통기계 오이넷사이트 젖팔계주소찾기 섹코링크 야동공장우회 일배야성인 꽁딸시즌2 체위종류 스포츠토토 YADONG 고니카지노 2019황금성솔루션 4tube접속